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They are probably part of the same disease spectrum rather than being two separate entities, with NBO thought to be the paediatric equivalent of SAPHO. For SAPHO syndrome, the age of presentation is from childhood to late adulthood, with a median age between 30 and 40 years. In adults, inflammation occurs mainly in the anterior chest wall but also in the spine, and less frequently in the iliac bones. This contrasts with NBO where the metaphyses and epiphyses of the long bones are most frequently affected, although pelvis, shoulder and spine can also be involved. Whole body MRI can be useful to look for lesions and to help confirm the diagnosis. It is important to exclude other pathology which can mimic both the clinical and radiological presentation.
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The dark side of SAPHO syndrome

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Rare disease: The dark side of SAPHO syndrome

Try out PMC Labs and tell us what you think. Learn More. SAPHO syndrome synovitis, acne, pustulosis, hyperostosis and osteitis is a relatively rare entity. The therapeutic approach of patients with SAPHO syndrome has included multiple drugs with varying success and incoherence responses.
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